Reproduction Abstracts

In the last decade, more and more studies have reported aberrant pattern of methylation in sperm DNA of patients with an altered spermogram. It is also admitted that epigenetic reprogramming during germ cell development is a key mechanism for the production of functional gametes and the proper development of the embryo. As poor semen quality is also a key issue for farm animals’ productivity, we studied the methylation profile of pig sperm DNA of fertile and poor-quality ...

Chromosomal rearrangements have a crucial impact on the proper proceedings of meiosis and can lead by several mechanisms to the production of unbalanced gametes or to the complete arrest of gametes production. To assess the impact of these rearrangement in the early development of pig germ cells, we proposed to generate a library of stem cells from an azoospermic boar carrying a reciprocal translocation t(Y:14), as a new tool for the development of an in vitro differe...